Article
Downregulation of RAR alpha in mice by antisense transgene leads to a compensatory increase in RAR beta and RAR gamma and development of lymphoma.
Blood - 1 Apr 1997
Manshouri T, Yang Y, Lin H, Stass S A, Glassman A B, Keating M J, Albitar M
Abstract excerpt
Retinoic acid receptors (RARs) alpha, beta, and gamma contain retinoic acid response elements (RAREs) in their promoter regions and respond to their own activation, thus forming an autoregulatory loop. We generated transgenic mice that expressed an antisense construct of the RAR alpha. Homozygous...
Topics
- Animals
- Cell Transformation, Neoplastic
- DNA, Antisense
- DNA, Complementary
- Down-Regulation
- Female
- Gene Expression Regulation, Neoplastic
- Homeostasis
- Humans
- Lymphoma
- Male
- Mice
- Mice, Transgenic
- Neoplasm Proteins
- Phenotype
- Receptors, Retinoic Acid
- Recombinant Fusion Proteins
- Retinoic Acid Receptor alpha