Article
UV-induced mutations in a shuttle vector replicated in repair deficient trichothiodystrophy cells differ with those in genetically-related cancer prone xeroderma pigmentosum.
Carcinogenesis - 1 Jul 1993
Madzak C, Armier J, Stary A, Daya-Grosjean L, Sarasin A
Abstract excerpt
Trichothiodystrophy (TTD) is a rare genetic disease associated in approximately 50% of patients with DNA repair deficiency analogous to that found in xeroderma pigmentosum group D (XP-D) patients. Although XP-D patients exhibit a very high level of skin cancer on sun-exposed parts, TTD is not ass...
Topics
- Base Sequence
- Cell Line, Transformed
- Cell Transformation, Viral
- Cells, Cultured
- DNA Repair
- DNA, Recombinant
- Hair Diseases
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- RNA, Transfer