Article
Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine.
Antimicrobial agents and chemotherapy - 1 May 2000
Richard N, Salomon H, Rando R, Mansour T, Bowlin T L, Wainberg M A
Abstract excerpt
Human immunodeficiency virus (HIV) type 1 (HIV-1) variants were selected for resistance to the (+) and (-) enantiomers of a novel nucleoside analogue, 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine (dOTFC), by use of the infectious molecular clone HIV HXB2D and the human T-cell line MT-4. The dOTFC-resistant variants that were selected were 10-fold less sensitive than wild-type virus, and cloning and sequencing of the...
Topics
- Anti-HIV Agents
- Deoxycytidine
- Drug Resistance, Microbial
- HIV-1
- Humans
- Microbial Sensitivity Tests
- Mutation
- Structure-Activity Relationship
- Thionucleosides