Article
Mutations at codon 184 in simian immunodeficiency virus reverse transcriptase confer resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.
Antimicrobial agents and chemotherapy - 1 Dec 1997
Cherry E, Slater M, Salomon H, Rud E, Wainberg M A
Abstract excerpt
Variants of simian immunodeficiency virus (SIV) that display greater than 2,000-fold resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine (3TC) were generated through in vitro passage and drug selection. The polymerase regions of several of these resistant viruses were sequenced and...
Topics
- Anti-HIV Agents
- Cell Line
- Cloning, Molecular
- Codon
- Drug Resistance, Microbial
- Humans
- Lamivudine
- Mutagenesis, Site-Directed
- Mutation
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors
- Simian Immunodeficiency Virus
- Stereoisomerism
- T-Lymphocytes
- Viral Proteins
- Virus Replication