Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

doi:10.1128/aac.37.4.875

Article

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 Apr 1993

Abstract excerpt

The (-) enantiomers of 2',3'-dideoxy-5-fluoro-3'-thiacytidine [(-)-FTC] and 2',3'-dideoxy-3'-thiacytidine [(-)-BCH-189] were recently shown to inhibit selectively human immunodeficiency viruses (HIV) and hepatitis B virus in vitro. In the current study, the potential for HIV type 1 (HIV-1) resistance to these compounds was evaluated by serial passage of the virus in human peripheral blood mononuclear cells and...

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