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DNA Damage and Cell Killing by Camptothecin and Its Derivative in Human Leukemia HL‐60 Cells

1 May 1993

Abstract excerpt

Camptothecin (CPT) has been recognized as a topoisomerase I (Topo I) inhibitor. However, the mechanism of cytotoxicity of this agent remains unknown. In the present study, we analyzed the kinetics of Topo I-mediated DNA single-strand breaks and internucleosomal DNA cleavage produced by CPT and its derivative, 7-ethyl-10-hydroxycamptothecin (SN-38), in HL-60 cells. DNA single-strand breaks were detected using...

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Identifiers

PMID: 8391526
DOI: 10.1111/j.1349-7006.1993.tb00177.x

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