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Article

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.

The Journal of biological chemistry - 25 Jul 2008

Lin Chao-Po, Ban Yi, Lyu Yi Lisa, Desai Shyamal D, Liu Leroy F

Abstract excerpt

Reversible topoisomerase I (Top1)-DNA cleavage complexes are the key DNA lesion induced by anticancer camptothecins (e.g. topotecan and irinotecan) as well as structurally perturbed DNAs (e.g. oxidatively damaged DNA, UV-irradiated DNA, alkylated DNA, uracil-substituted DNA, mismatched DNA, gapped and nicked DNA, and DNA with abasic sites). Top1 cleavage complexes arrest transcription and trigger...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18515798
DOI: 10.1074/jbc.M803493200
PMCID: PMC2475699

Genes

ATM
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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