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Article

DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.

Cancer biochemistry biophysics - 1 Jan 1990

Ling Y H, Andersson B S, Nelson J A

Abstract excerpt

We investigated the antiproliferative effect of 10-hydroxycamptothecin (HCPT), an alkaloid isolated from Camptotheca acuminata, on the human promyelocytic leukemia cell line, HL-60, and a 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA)-resistant mutant, HL-60/m-AMSA. Using trypan blue dye exclusion and colony formation, doses of HCPT ranging from 0.01 to 1 microM progressively inhibited growth in both...

Topics

Amsacrine
Antineoplastic Agents, Phytogenic
Camptothecin
Cell Division
DNA Damage
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
Drug Resistance
Enzyme Inhibitors
Etoposide
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Promyelocytic, Acute

Mutation

Topoisomerase I Inhibitors

Topoisomerase II Inhibitors

Tumor Cells, Cultured

Source

Identifiers

PMID: 2159843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2159843-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.PMID 2159843Read ↗

DNA Damage and Cell Killing by Camptothecin and Its Derivative in Human Leukemia HL‐60 CellsSemantic proximity Read ↗

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.Semantic proximity Read ↗

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Identification of mutations at DNA topoisomerase I responsible for camptothecin resistance.Semantic proximity Read ↗

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