Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1

1 Jun 2009

Abstract excerpt

Intratumoral hypoxia is associated with resistance to therapy in many human cancers, and preexposure of tumor cells to hypoxia confers multidrug resistance. Whereas most anticancer drugs kill proliferating tumor cells by causing DNA damage, a role for hypoxia in the prevention and/or repair of drug-induced DNA damage has not been clear. Using the alkaline comet assay, we provide direct evidence that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Lipids, and Metabolism
Share to Lung Cancer Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19509259
DOI: 10.1158/1535-7163.mct-08-1090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1PMID 19509259Read ↗

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity.Semantic proximity Read ↗

Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instabilitySemantic proximity Read ↗

Chronic hypoxia promotes hypoxia-inducible factor-1α–dependent resistance to etoposide and vincristine in neuroblastoma cellsSemantic proximity Read ↗

Hypoxic stress proteins: Survival of the fittestSemantic proximity Read ↗

Effect of Transient Hypoxia on Sensitivity to Doxorubicin in Human and Murine Cell LinesSemantic proximity Read ↗

HIF-1 Signaling in Drug Resistance to ChemotherapySemantic proximity Read ↗

The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1α Activity by Changing miR Expression Patterns in Human Cancer CellsSemantic proximity Read ↗

HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responsesSemantic proximity Read ↗

Diminished Carcinogen Detoxification Is a Novel Mechanism for Hypoxia-inducible Factor 1-mediated Genetic InstabilitySemantic proximity Read ↗

Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapySemantic proximity Read ↗

Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells.Semantic proximity Read ↗

Assessment of chemotherapy‐induced DNA damage in peripheral blood leukocytes of cancer patients using the alkaline comet assaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.