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Etoposide Quinone Is a Redox-Dependent Topoisomerase II Poison

19 May 2011

Abstract excerpt

Etoposide is a topoisomerase II poison that is used to treat a variety of human cancers. Unfortunately, 2-3% of patients treated with etoposide develop treatment-related leukemias characterized by 11q23 chromosomal rearrangements. The molecular basis for etoposide-induced leukemogenesis is not understood but is associated with enzyme-mediated DNA cleavage. Etoposide is metabolized by CYP3A4 to etoposide catechol,...

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PMID: 21595477
DOI: 10.1021/bi200438m

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