The Current Status of Camptothecin Analogues as Antitumor Agents

doi:10.1093/jnci/85.4.271

Article

The Current Status of Camptothecin Analogues as Antitumor Agents

17 Feb 1993

Abstract excerpt

The nuclear enzyme topoisomerase I (topo I) has been recently recognized as the target for the anticancer drug camptothecin (CPT) and its derivatives. Two of the agents that target this enzyme--topotecan (TPT) and CPT-11--appear to be active against a broad range of human tumors. In the following presentation, we review 1) the role of topo I in normal cells, 2) the chemistry and proposed mechanism of action of...

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