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Article

Phenotypic suppression by incorporation of an alien amino acid.

Journal of molecular biology - 20 May 1993

Lemeignan B, Sonigo P, Marlière P

Abstract excerpt

Azaleucine is a naturally occurring amino acid antibiotic that can be incorporated into proteins by mimicking leucine. In spite of its highly toxic character, the contrast between the hydrophobic side-chain of leucine and the basic side-chain of azaleucine suggested a mechanism for rescuing certa...

Topics

Amino Acids
Arginine
Codon
Escherichia coli
Leucine
Nucleoside-Phosphate Kinase
Phenotype
Protein Biosynthesis
Protein Engineering
Suppression, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8389880
DOI: 10.1006/jmbi.1993.1269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8389880-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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