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Article

Phenotypic suppression by incorporation of an alien amino acid.

Journal of molecular biology - 20 May 1993

Lemeignan B, Sonigo P, Marlière P

Abstract excerpt

Azaleucine is a naturally occurring amino acid antibiotic that can be incorporated into proteins by mimicking leucine. In spite of its highly toxic character, the contrast between the hydrophobic side-chain of leucine and the basic side-chain of azaleucine suggested a mechanism for rescuing certain mutants. We constructed a thymidine auxotrophic mutant of Escherichia coli by replacing an arginine residue with...

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Identifiers

PMID: 8389880
DOI: 10.1006/jmbi.1993.1269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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