Article
Mutant insulin receptors in syndromes of insulin resistance.
Bailliere's clinical endocrinology and metabolism - 1 Jan 1996
Krook A, O'Rahilly S
Abstract excerpt
To date, mutations of the insulin receptor remain the only well-established causes of severe insulin resistance. There is a broad correlation between the extent of impairment of signal transduction seen when the mutant receptors are expressed in vitro with the severity of the clinical phenotype....
Topics
- Humans
- Insulin
- Insulin Resistance
- Mutation
- Receptor, Insulin
- Structure-Activity Relationship