Article
Poliovirus attenuation and pathogenesis in a transgenic mouse model for poliomyelitis.
Developments in biological standardization - 1 Jan 1993
Racaniello V R, Ren R, Bouchard M
Abstract excerpt
A transgenic mouse model for poliomyelitis has been used to study aspects of poliovirus attenuation and pathogenesis. Transgenic mice expressing the cell receptor for poliovirus (TgPVR mice) develop poliomyelitis after inoculation with poliovirus by a variety of routes. TgPVR mice have been used to identify genomic sequences responsible for the attenuation phenotype of the P1/Sabin and P2/Sabin vaccine strains....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.