A Transgenic Mouse Model of Poliomyelitis.

doi:10.1007/978-1-4939-3292-4_7

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Article

A Transgenic Mouse Model of Poliomyelitis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Koike Satoshi, Nagata Noriyo

Abstract excerpt

Transgenic mice (tg mice) that express the human poliovirus receptor (PVR), CD155, are susceptible to poliovirus and develop a neurological disease that resembles human poliomyelitis. Assessment of the neurovirulence levels of poliovirus strains, including mutant viruses produced by reverse genetics, circulating vaccine-derived poliovirus, and vaccine candidates, is useful for basic research of poliovirus...

Topics

Animals
Antigens, Viral
Disease Models, Animal
Genotyping Techniques
Humans
Immunity, Innate
Mice
Mice, Knockout
Mice, Transgenic
Mutation
Poliomyelitis
Poliovirus
Receptors, Virus

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PMID: 26983733
DOI: 10.1007/978-1-4939-3292-4_7

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