Article
Poliovirus-sensitive transgenic mice as a new animal model.
Developments in biological standardization - 1 Jan 1993
Koike S, Horie H, Sato Y, Ise I, Taya C, Nomura T, Yoshioka I, Yonekawa H, Nomoto A
Abstract excerpt
Transgenic mice susceptible to poliovirus infection were produced by introducing a human gene encoding cellular receptors for poliovirus into the mouse genome. Expression of receptor mRNAs in tissues of the transgenic mice was analysed using Northern blot hybridization. The results indicate that the human gene is expressed in many tissues of the transgenic mice just as in human tissues, and that the amount of the...
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