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Article

Infectious cDNA, cell receptors and transgenic mice in the study of Sabin's poliovirus vaccines.

Biologicals : journal of the International Association of Biological Standardization - 1 Dec 1993

Racaniello V R

Abstract excerpt

The determination of the nucleotide sequence of the poliovirus genome, the isolation of infectious poliovirus cDNAs, and the identification of the cell receptor for poliovirus and establishment of a transgenic mouse model for poliomyelitis have all contributed to our understanding of the live, attenuated Sabin poliovirus vaccines. These highly effective vaccines have been studied extensively by many laboratories...

Topics

Animals
Central Nervous System
DNA, Complementary
Genetic Predisposition to Disease
History, 20th Century
Humans
Membrane Proteins
Mice
Mice, Transgenic
Organ Specificity
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poliovirus

Poliovirus Vaccine, Oral

Receptors, Virus

Virulence

Source

Identifiers

PMID: 8024752
DOI: 10.1006/biol.1993.1097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8024752-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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