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Article

Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice.

Journal of virology - 1 Jan 1992

Ren R, Racaniello V R

Abstract excerpt

Expression of the human poliovirus receptor (PVR) in transgenic mice results in susceptibility to poliovirus infection. In the primate host, poliovirus infection is characterized by restricted tissue tropism. To determine the pattern of poliovirus tissue tropism in PVR transgenic mice, PVR gene expression and susceptibility to poliovirus infection were examined by in situ hybridization. PVR RNA is expressed in...

Topics

Animals
Central Nervous System
Gene Expression
Genetic Predisposition to Disease
Humans
Kidney
Mice
Mice, Transgenic
Nucleic Acid Hybridization
Poliomyelitis
Poliovirus
RNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

Receptors, Virus

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1370085
DOI: 10.1128/JVI.66.1.296-304.1992
PMCID: PMC238287

Genes

PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370085-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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