Article
DNA topoisomerases and the DNA lesion in human genetic instability syndromes.
Toxicology letters - 1 Apr 1993
Poot M, Hoehn H
Abstract excerpt
Genetically determined chromosomal instability entails, among other sequelae, a condition of elevated cancer risk. Patients with the autosomal recessive disorder Fanconi's anemia (FA) often develop leukemias of the monocytic lineage together with pancytopenia, whereas the Bloom's syndrome (BS) mu...
Topics
- Bloom Syndrome
- Cell Cycle
- DNA Topoisomerases, Type I
- DNA Topoisomerases, Type II
- Fanconi Anemia
- Genetic Predisposition to Disease
- Humans
- Mutation
- Neoplasms