Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype.

doi:10.1111/j.1600-0609.2005.00507.x

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Article

Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype.

European journal of haematology - 1 Aug 2005

Pagano Giovanni, Degan Paolo, d'Ischia Marco, Kelly Frank J, Nobili Bruno, Pallardó Federico V, Youssoufian Hagop, Zatterale Adriana

Abstract excerpt

Fanconi anaemia (FA) is a genetic disease characterised by bone marrow failure with excess risk of myelogenous leukaemia and solid tumours. A widely accepted notion in FA research invokes a deficiency of response to DNA damage as the fundamental basis of the 'crosslinker sensitivity' observed in this disorder. However, such an isolated defect cannot readily account for the full cellular and clinical phenotype,...

Topics

Cell Cycle Proteins
DNA-Binding Proteins
Fanconi Anemia
Fanconi Anemia Complementation Group Proteins
Humans
Nuclear Proteins
Oxidation-Reduction
Oxidative Stress
Phenotype

Source

Open in PubMed

Identifiers

PMID: 16000125
DOI: 10.1111/j.1600-0609.2005.00507.x

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