Article
Fanconi anemia: a pleotropic mutation with multiple cellular and developmental abnormalities.
Annales de genetique - 1 Jan 1991
Chaganti R S, Houldsworth J
Abstract excerpt
Fanconi anemia (FA), an autosomal recessive disorder of children, is characterized by congenital or childhood aplastic anemia, multiple developmental anomalies, increased incidence of myeloid leukemia, increased spontaneous chromosome breakage, and cellular and chromosomal hypersensitivity to DNA bifunctional crosslinking and alkylating agents. Attempts to understand the biochemical basis of the disorder over the...
Topics
- Abnormalities, Multiple
- Anemia, Aplastic
- Chromosome Aberrations
- Chromosome Disorders
- Cross-Linking Reagents
- DNA
- Fanconi Anemia
- Genes, Recessive
- Humans
- Mutation
- Neoplasms