Genetic disorders associated with cancer predisposition and genomic instability.

Abstract excerpt

Genomic instability in its broadest sense is a feature of virtually all neoplastic cells. In addition to the mutations and/or gene amplifications that appear to be a prerequisite for the acquisition of a neoplastic phenotype, human cancers exhibit other "markers" of genomic instability--in particular, a high degree of aneuploidy. Indeed, many studies have shown that aneuploidy is an almost invariant feature of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Diseases, Inborn
• Share to Genetic Predisposition to Disease