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Article

Simian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells.

Journal of virology - 1 Apr 1993

Kao C, Hauser P, Reznikoff W S, Reznikoff C A

Abstract excerpt

pSV2Neo, a plasmid that contains the wild-type simian virus 40 (SV40) origin of replication (ori), is widely used in mammalian cell transfection experiments. We observed that pSV2Neo transforms two nontumorigenic SV40-immortalized human uroepithelial cell lines (SV-HUC and CK/SV-HUC2) to G418 resistance (G418r) at a frequency lower than that at which it transforms SV-HUC tumorigenic derivatives (T-SV-HUC)....

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Identifiers

PMID: 8383222
DOI: 10.1128/JVI.67.4.1987-1995.1993
PMCID: PMC240267

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Source receipt: pubmed, retrieved 7 Sept 2026.

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