Article
Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells.
International journal of molecular sciences - 7 Nov 2021
Hong Lenny K, Kadkol Shrinidhi, Sverdlov Maria, Kastrati Irida, Elhodaky Mostafa, Deaton Ryan, Sfanos Karen S, Wang Heidi, Liu Li, Diamond Alan M
Abstract excerpt
SELENOF is a member of the class of selenoproteins in which the amino acid selenocysteine is co-translationally inserted into the elongating peptide in response to an in-frame UGA codon located in the 3'-untranslated (3'-UTR) region of the SELENOF mRNA. Polymorphisms in the 3'-UTR are associated with an increased risk of dying from prostate cancer and these variations are functional and 10 times more frequent in...
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