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Article

Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.

Cell - 10 Aug 2001

Dhar S K, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel J A, Leffak M, Yates J, Dutta A

Abstract excerpt

A hypomorphic mutation made in the ORC2 gene of a human cancer cell line through homologous recombination decreased Orc2 protein levels by 90%. The G1 phase of the cell cycle was prolonged, but there was no effect on the utilization of either the c-Myc or beta-globin cellular origins of replication. Cells carrying this mutation failed to support the replication of a plasmid bearing the oriP replicator of Epstein...

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Share to Epstein-Barr Virus Nuclear Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Herpesvirus 4, Human

Share to Origin Recognition Complex

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Source

Identifiers

PMID: 11509178
DOI: 10.1016/s0092-8674(01)00458-5

Genes

ORC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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