Neoplastic progression by EJ/ras at different steps of transformation in vitro of human uroepithelial cells.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Neoplastic progression by EJ/ras at different steps of transformation in vitro of human uroepithelial cells.

Cancer research - 1 Feb 1992

Pratt C I, Kao C H, Wu S Q, Gilchrist K W, Oyasu R, Reznikoff C A

Abstract excerpt

The biological effects of expression of mutant ras at different stages of human uroepithelial cell (HUC) tumorigenesis were tested after transfection of EJ/ras into nonestablished HUC and three isogeneic cell lines representing different steps in HUC transformation in vitro. Transfection with EJ/ras failed to immortalize diploid HUC and also failed to cause tumorigenic conversion of a near-diploid...

Topics

3T3 Cells
Animals
Cell Division
Cell Line, Transformed
Cell Transformation, Neoplastic
Cells, Cultured
Chromosome Banding
Epithelial Cells
Female
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Karyotyping

Mice

Mice, Nude

Mitosis

Mutation

Neoplasm Invasiveness

Neoplasm Transplantation

Source

Open in PubMed

Identifiers

PMID: 1310069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1310069-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neoplastic progression by EJ/ras at different steps of transformation in vitro of human uroepithelial cells.PMID 1310069Read ↗

Nonrandom chromosome losses in tumorigenic revertants of hybrids between isogeneic immortal and neoplastic human uroepithelial cells.Semantic proximity Read ↗

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).Semantic proximity Read ↗

Simian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells.Semantic proximity Read ↗

Allelic 3p deletions in high-grade carcinomas after transformation in vitro of human uroepithelial cells.Semantic proximity Read ↗

Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.Semantic proximity Read ↗

Genetic analysis of an in vitro model system for human papillomavirus type 16-associated tumorigenesis.Semantic proximity Read ↗

Use of an anti-ras ribozyme to alter the malignant phenotype of a human bladder cancer cell line.Semantic proximity Read ↗

Reversal of the malignant phenotype by an anti-ras ribozyme.Semantic proximity Read ↗

Human papillomavirus 18-immortalized endocervical cells with in vitro cytokeratin expression characteristics of adenocarcinoma.Semantic proximity Read ↗

Stepwise immortalization and transformation of adult human prostate epithelial cells by a combination of HPV-18 and v-Ki-ras.Semantic proximity Read ↗

Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathwaySemantic proximity Read ↗

Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.