Article
Neoplastic progression by EJ/ras at different steps of transformation in vitro of human uroepithelial cells.
Cancer research - 1 Feb 1992
Pratt C I, Kao C H, Wu S Q, Gilchrist K W, Oyasu R, Reznikoff C A
Abstract excerpt
The biological effects of expression of mutant ras at different stages of human uroepithelial cell (HUC) tumorigenesis were tested after transfection of EJ/ras into nonestablished HUC and three isogeneic cell lines representing different steps in HUC transformation in vitro. Transfection with EJ/ras failed to immortalize diploid HUC and also failed to cause tumorigenic conversion of a near-diploid...
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