Allelic 3p deletions in high-grade carcinomas after transformation in vitro of human uroepithelial cells.

doi:10.1002/gcc.2870030505

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Article

Allelic 3p deletions in high-grade carcinomas after transformation in vitro of human uroepithelial cells.

Genes, chromosomes & cancer - 1 Sept 1991

Klingelhutz A J, Wu S Q, Bookland E A, Reznikoff C A

Abstract excerpt

Restriction fragment length polymorphism (RFLP) analysis for allelic losses on the chromosome arm 3p were performed on independent carcinomas produced in athymic nude mice after transformation in vitro of a pseudodiploid clonal SV40-immortalized human uroepithelial cell line (SV-HUC). We analyzed ten primary carcinomas with heterogeneous phenotypes for deletions on 3p by using three informative probes, D3S30,...

Topics

Alleles
Animals
Carcinoma
Cell Line
Cell Line, Transformed
Cell Transformation, Neoplastic
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 3
Epithelium
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Karyotyping

Mice

Mice, Nude

Neoplasm Transplantation

Phenotype

Polymorphism, Restriction Fragment Length

Transplantation, Heterologous

Source

Open in PubMed

Identifiers

PMID: 1686726
DOI: 10.1002/gcc.2870030505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1686726-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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