Use of an anti-ras ribozyme to alter the malignant phenotype of a human bladder cancer cell line.

Abstract excerpt

PURPOSE: In this study, we evaluated the ability of a ribozyme (catalytic RNA), which site specifically cleaves the mRNA of the activated H-ras gene, to alter the malignant phenotype of an invasive human bladder cancer cell line. MATERIALS AND METHODS: The human bladder cancer cell line EJ which contains the activated H-ras gene was used in these studies. Cell lines with and without the anti-ras ribozyme were...

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