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Article

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991

Bugg B Y, Danks M K, Beck W T, Suttle D P

Abstract excerpt

Nuclear extracts from teniposide (VM-26)-resistant sublines of the human leukemic cell line CCRF-CEM have decreased levels of DNA topoisomerase II catalytic activity and decreased capacity to form drug-stabilized covalent protein-DNA complexes. The ATP concentration required for equivalent activi...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Topoisomerases, Type II
Drug Resistance
Gene Expression
Humans
Molecular Sequence Data
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Sequence Homology, Nucleic Acid

Teniposide

Source

Open in PubMed Open full text

Identifiers

PMID: 1652758
DOI: 10.1073/pnas.88.17.7654
PMCID: PMC52360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1652758-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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