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Article

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1991

Bugg B Y, Danks M K, Beck W T, Suttle D P

Abstract excerpt

Nuclear extracts from teniposide (VM-26)-resistant sublines of the human leukemic cell line CCRF-CEM have decreased levels of DNA topoisomerase II catalytic activity and decreased capacity to form drug-stabilized covalent protein-DNA complexes. The ATP concentration required for equivalent activity in a DNA-unknotting assay is 2- to 8-fold higher in nuclear extracts from drug-resistant cell lines as compared with...

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Identifiers

PMID: 1652758
DOI: 10.1073/pnas.88.17.7654
PMCID: PMC52360

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Source receipt: pubmed, retrieved 7 Sept 2026.

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