Article
Teniposide-resistant CEM cells, which express mutant DNA topoisomerase II alpha, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme.
Cancer research - 15 Dec 1993
Chen M, Beck W T
Abstract excerpt
We have examined the effects of a group of DNA topoisomerase II (topo II) inhibitors, merbarone, aclarubicin, SN22995, RP60475F, and fostriecin, in CCRF-CEM cells and two sublines, CEM/VM-1 and CEM/VM-1-5, that were selected for increasing resistance to teniposide (VM-26). The teniposide-resistan...
Topics
- Cell Cycle
- Chromosomes
- DNA
- DNA Topoisomerases, Type II
- Drug Resistance
- Humans
- Leukemia
- Mutation
- Proteins
- Teniposide
- Thiobarbiturates
- Topoisomerase II Inhibitors