Article
Pharmacologic validation of human tumor clonogenic assays based on pleiotropic drug resistance: implications for individualized chemotherapy and new drug screening programs.
International journal of cell cloning - 1 Nov 1992
Parchment R E, Soleimanpour K, Petrose S, Murphy M J
Abstract excerpt
Because of the bias toward successful cloning of human tumor cells from more advanced malignancies, alternative approaches to clinical correlations of drug resistance are needed to determine the validity of the human tumor clonogenic assay (HTCA) as a clinically useful test. Capitalizing on the prevalence of clinical drug resistance among these advanced malignancies, we have taken an independent approach to...
Topics
- Antineoplastic Agents
- DNA Topoisomerases, Type II
- Databases, Bibliographic
- Drug Resistance
- Phenotype
- Retrospective Studies
- Tumor Stem Cell Assay