The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.

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Article

The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.

Oncogene - 2 Feb 1995

Huen D S, Henderson S A, Croom-Carter D, Rowe M

Abstract excerpt

The Epstein-Barr virus (EBV) encoded latent membrane protein, LMP1, is oncogenic in rodent fibroblasts and is an essential effector protein in EBV-induced growth-transformation of human B lymphocytes. Previous structure-function studies with LMP1 have relied largely on rodent fibroblast transformation as a functional readout, with apparently conflicting results. We have now analysed several LMP1 mutants in...

Topics

Animals
Antigens, CD
Antigens, Viral
Base Sequence
Cell Line
Chlorocebus aethiops
Herpesvirus 4, Human
Humans
Immunophenotyping
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-kappa B

Rats

Structure-Activity Relationship

Transfection

Tumor Cells, Cultured

Viral Matrix Proteins

Source

Open in PubMed

Identifiers

PMID: 7845680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7845680-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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