Article
Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation.
Journal of virology - 1 Jul 1994
Izumi K M, Kaye K M, Kieff E D
Abstract excerpt
Previous recombinant Epstein-Barr virus molecular genetic experiments with specifically mutated LMP1 genes indicate that LMP1 is essential for primary B-lymphocyte growth transformation and that the amino-terminal cytoplasmic and first transmembrane domains are together an important mediator of transformation. EBV recombinants with specific deletions in the amino-terminal cytoplasmic domain have now been...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Viral
- B-Lymphocytes
- Base Sequence
- Callithrix
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cell Transformation, Viral