Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways.

Biochemistry. Biokhimiia - 1 Oct 2008

Diduk S V, Smirnova K V, Pavlish O A, Gurtsevitch V E

Abstract excerpt

Latent membrane protein 1 (LMP1) of the Epstein-Barr virus is a constitutively activated analog of the tumor necrosis factor receptor TNF-R1. LMP1 serves as a viral oncogene able to transform human B-lymphocytes and rodent fibroblasts via activation of numerous cellular signal cascades. Two specific motifs within LMP1 are responsible for interaction of this viral protein with the receptor protein beta-TrCP/HOS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblasts

Share to NF-kappa B

Share to Nitric Oxide

Share to Phosphatidylinositol 3-Kinases

Share to Viral Matrix Proteins

Source

Identifiers

PMID: 18991560
DOI: 10.1134/s0006297908100106

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways.PMID 18991560Read ↗

The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.Semantic proximity Read ↗

The Role of Epstein-Barr Virus in Neoplastic TransformationSemantic proximity Read ↗

A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways.Semantic proximity Read ↗

LMP1 strain variants: biological and molecular properties.Semantic proximity Read ↗

The Latent Membrane Protein 1 (LMP1) Oncogene of Epstein-Barr Virus Can Simultaneously Induce and Inhibit Apoptosis in B CellsSemantic proximity Read ↗

[Functional analysis of Epstein-Barr virus latent membrane proteins (LMP1) in patients with limphoproliferative disorders].Semantic proximity Read ↗

Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.Semantic proximity Read ↗

Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus.Semantic proximity Read ↗

Mutational analysis of the transforming function of the EBV encoded LMP-1.Semantic proximity Read ↗

Natural 30 base pair and 69 base pair deletion variants of the LMP1 oncogene do stimulate NF-kappaB-mediated transcription.Semantic proximity Read ↗

Degradation of the epstein-barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue.Semantic proximity Read ↗

Epstein-Barr virus LMP-1 natural sequence variants differ in their potential to activate cellular signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.