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Article

Unique Signaling Properties of CTAR1 in LMP1-Mediated Transformation

12 Jul 2007

Abstract excerpt

The Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) gene is considered the EBV oncogene as it is necessary for EBV-mediated transformation of B lymphocytes and itself transforms rodent fibroblasts. LMP1 activates the NF-kappaB, phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase, and Jun N-terminal protein kinase signaling pathways through its two signaling domains,...

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PMID: 17626074
DOI: 10.1128/jvi.01001-07

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