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Article

A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways.

Oncogene - 8 Apr 2004

Adriaenssens Eric, Mougel Alexandra, Goormachtigh Gautier, Loing Estelle, Fafeur Véronique, Auriault Claude, Coll Jean

Abstract excerpt

The latent membrane protein-1 (LMP1) is an integral membrane molecule expressed by Epstein-Barr virus (EBV) during viral latency and displays properties of a constitutively activated member of the TNF receptor family. LMP1 is required for B-cell or monocyte immortalization induced by EBV and is sufficient to transform rodent fibroblasts. Transforming potential of LMP1 is mediated by its cytoplasmic C-terminal...

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Identifiers

PMID: 14767477
DOI: 10.1038/sj.onc.1207432

Genes

TNF
TRADD
TRAF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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