Determination of diabetogenicity attributable to a single amino acid, Ala776, on the polyprotein of encephalomyocarditis virus.

doi:10.2337/diab.42.3.435

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Article

Determination of diabetogenicity attributable to a single amino acid, Ala776, on the polyprotein of encephalomyocarditis virus.

Diabetes - 1 Mar 1993

Bae Y S, Yoon J W

Abstract excerpt

The best experimental evidence indicating that viruses have an etiological role in the pathogenesis of diabetes comes from studies of mice infected with EMC virus. For this study we generated mutant viruses from stocks of diabetogenic EMC-D and nondiabetogenic EMC-B viruses by serial passages of...

Topics

Alanine
Animals
Base Sequence
Capsid
Capsid Proteins
DNA, Viral
Diabetes Mellitus, Type 1
Encephalomyocarditis virus
Male
Mice
Molecular Sequence Data
Mutation

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