Article
Phenotypic and genetic changes in coxsackievirus B5 following repeated passage in mouse pancreas in vivo.
Journal of medical virology - 1 Apr 2005
Al-Hello Haider, Davydova Berta, Smura Teemu, Kaialainen Svetlana, Ylipaasto Petri, Saario Elise, Hovi Tapani, Rieder Elizabeth, Roivainen Merja
Abstract excerpt
Common enterovirus infections appear to initiate or facilitate the pathogenetic processes leading to type 1 diabetes, and also sometimes precipitate the clinical disease. In experimental infection of mice, coxsackieviruses have shown to have a strong affinity for the exocrine tissue, while even in lethal cases, the islets remain unaffected. The virus strain most intensively studied in this respect is the...
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