Two amino acids, Phe 16 and Ala 776, on the polyprotein are most likely to be responsible for the diabetogenicity of encephalomyocarditis virus.

doi:10.1099/0022-1317-71-3-639

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Two amino acids, Phe 16 and Ala 776, on the polyprotein are most likely to be responsible for the diabetogenicity of encephalomyocarditis virus.

The Journal of general virology - 1 Mar 1990

Bae Y S, Eun H M, Pon R T, Giron D, Yoon J W

Abstract excerpt

The diabetogenic D variant of encephalomyocarditis virus (EMC-D) was previously shown to differ from the non-diabetogenic B variant (EMC-B) by 14 nucleotides out of 7829 bases. Similar approaches with a new nondiabetogenic variant, EMC-DV1, obtained by plaque purification of the EMC-D variant stock pool, enabled us to narrow down further the possible genomic area responsible for the diabetogenicity of EMC virus....

Topics

Alanine
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Codon
DNA, Viral
Diabetes Mellitus, Experimental
Encephalomyocarditis virus
Genes, Viral
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferons

L Cells

Male

Mice

Mice, Inbred Strains

Molecular Sequence Data

Phenylalanine

Source

Open in PubMed

Identifiers

PMID: 1690262
DOI: 10.1099/0022-1317-71-3-639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1690262-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two amino acids, Phe 16 and Ala 776, on the polyprotein are most likely to be responsible for the diabetogenicity of encephalomyocarditis virus.PMID 1690262Read ↗

Determination of diabetogenicity attributable to a single amino acid, Ala776, on the polyprotein of encephalomyocarditis virus.Semantic proximity Read ↗

Construction and characterization of two infectious molecular clones of encephalomyocarditis virus.Semantic proximity Read ↗

Analysis of sequence and pathogenic properties of two variants of encephalomyocarditis virus differing in a single amino acid in VP1.Semantic proximity Read ↗

The encephalomyocarditis virusSemantic proximity Read ↗

Encephalomyocarditis Virus 2A Protein Is Required for Viral Pathogenesis and Inhibition of ApoptosisSemantic proximity Read ↗

Major 5′terminally deleted enterovirus populations modulate type I IFN response in acute myocarditis patients and in human cultured cardiomyocytesSemantic proximity Read ↗

Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replicationSemantic proximity Read ↗

Molecular and biological analysis of echovirus 9 strain isolated from a diabetic childSemantic proximity Read ↗

Involvement of cardiovirus leader in hostcell-restricted virus expression.Semantic proximity Read ↗

Molecular epidemiology of enteroviruses with special reference to their potential role in the etiology of insulin-dependent diabetes mellitus (IDDM). A review.Semantic proximity Read ↗

Coxsackievirus can persist in murine pancreas by deletion of 5′ terminal genomic sequencesSemantic proximity Read ↗

Identification of functionally important negatively charged residues in the carboxy end of mouse hepatitis coronavirus A59 nucleocapsid protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.