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Article

HPLC is an effective and fast method for analysis of viral proteins: a study of encephalomyocarditis virus mutants differing in pathogenicity.

The Journal of general virology - 1 Dec 1993

Zimmermann A, Mertens T, Schulz A, Kruppenbacher J P, Nelsen-Salz B, Eggers H J

Abstract excerpt

We investigated the use of HPLC in analysis of picornavirus variants by comparing structural polypeptides of three stable mutants of encephalomyocarditis virus (EMCV). The variants are known to differ in their pathogenicity for mice: plaque variant 2 (PV2) is diabetogenic, PV7 is non-diabetogenic...

Topics

Capsid
Capsid Proteins
Chromatography, High Pressure Liquid
Encephalomyocarditis virus
Genetic Variation
Mutation
Peptide Fragments
Trypsin
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8277283
DOI: 10.1099/0022-1317-74-12-2759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8277283-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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