Article
Identification of functionally important negatively charged residues in the carboxy end of mouse hepatitis coronavirus A59 nucleocapsid protein.
Journal of virology - 1 May 2006
Verma Sandhya, Bednar Valerie, Blount Andrew, Hogue Brenda G
Abstract excerpt
The coronavirus nucleocapsid (N) protein is a multifunctional viral gene product that encapsidates the RNA genome and also plays some as yet not fully defined role in viral RNA replication and/or transcription. A number of conserved negatively charged amino acids are located within domain III in the carboxy end of all coronavirus N proteins. Previous studies suggested that the negatively charged residues are...
Topics
- Amino Acid Sequence
- Animals
- Aspartic Acid
- Cell Line
- Coronavirus Nucleocapsid Proteins
- Ions
- Isoelectric Point
- Kinetics
- Mice
- Molecular Sequence Data
- Murine hepatitis virus
- Mutation
- Nucleocapsid Proteins
- Sequence Alignment