Article
Analysis of sequence and pathogenic properties of two variants of encephalomyocarditis virus differing in a single amino acid in VP1.
Virus research - 1 Apr 1996
Nelsen-Salz B, Zimmermann A, Wickert S, Arnold G, Botta A, Eggers H J, Kruppenbacher J P
Abstract excerpt
The encephalomyocarditis (EMC) virus-induced diabetes-like syndrome in mouse inbred strains was used as a model to study the insulin-dependent diabetes mellitus (IDDM). Our investigations were performed with two EMC virus variants, PV2 and PV7. After infection of SJL mice with 10(5) PFU of PV2 ab...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Capsid
- Capsid Proteins
- Cardiovirus Infections
- Disease Models, Animal
- Encephalomyocarditis virus
- Genetic Variation
- In Situ Hybridization
- Male
- Mice
- Molecular Sequence Data
- Point Mutation
- RNA, Viral
- Sequence Analysis