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Article

Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

American journal of human genetics - 1 Feb 1993

Olschwang S, Laurent-Puig P, Groden J, White R, Thomas G

Abstract excerpt

The first 14 exons of the APC gene have been screened by the denaturation gradient gel electrophoresis method in 160 unrelated patients with familial adenomatous polyposis coli (APC) syndrome. Four polymorphic variants corresponding to silent mutations not associated with the disease phenotype were observed. Mutations predicted to alter the coding property of the APC gene were observed in 26 patients. All these...

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Identifiers

PMID: 8381580
PMCID: PMC1682179

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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