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Article

Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1994

Dobbie Z, Spycher M, Hürliman R, Ammann R, Ammann T, Roth J, Müller A, Müller H, Scott R J

Abstract excerpt

In the present study, the polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) technique has been applied to the mutation analysis of the adenomatous polyposis coli (APC) gene. We examined the first 14 exons of the APC gene in 46 polyposis coli patients. Five germline mutations were observed, including a single-nucleotide substitution and small (1-4 bp) deletions leading, in 4 cases, to a...

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Source

Identifiers

PMID: 7833149
DOI: 10.1016/0959-8049(94)00294-f

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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