Article
Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Dobbie Z, Spycher M, Hürliman R, Ammann R, Ammann T, Roth J, Müller A, Müller H, Scott R J
Abstract excerpt
In the present study, the polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) technique has been applied to the mutation analysis of the adenomatous polyposis coli (APC) gene. We examined the first 14 exons of the APC gene in 46 polyposis coli patients. Five germline muta...
Topics
- Adenomatous Polyposis Coli
- Adult
- Aged
- Base Sequence
- DNA Mutational Analysis
- Exons
- Female
- Genes, APC
- Germ-Line Mutation
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational