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Article

Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.

American journal of human genetics - 1 Feb 1993

Varesco L, Gismondi V, James R, Robertson M, Grammatico P, Groden J, Casarino L, De Benedetti L, Bafico A, Bertario L

Abstract excerpt

The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer. It is also implicated in the development of sporadic colorectal tumors. The characterization of APC gene mutations in APC patients is clinically important because DNA-based tests can be applied for presymptomatic diagnosis once a specific...

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Identifiers

PMID: 8381581
PMCID: PMC1682198

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.PMID 8381581Read ↗

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Screening for mutations of the APC gene in 66 Italian familial adenomatous polyposis patients: evidence for phenotypic differences in cases with and without identified mutation.Semantic proximity Read ↗

APC gene mutations causing familial adenomatous polyposis in Polish patients.Semantic proximity Read ↗

Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.Semantic proximity Read ↗

Nine novel APC mutations in Italian FAP patients.Semantic proximity Read ↗

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Characterization of APC exon 15 germ-line mutation in FAP family with severe phenotype showing extracolonic symptoms.Semantic proximity Read ↗

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Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients.Semantic proximity Read ↗

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