Article
Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis.
Genomics - 1 Aug 1992
Fodde R, van der Luijt R, Wijnen J, Tops C, van der Klift H, van Leeuwen-Cornelisse I, Griffioen G, Vasen H, Khan P M
Abstract excerpt
Familial adenomatous polyposis (FAP) is a dominantly inherited condition predisposing to colorectal cancer. The recent isolation of the responsible gene (adenomatous polyposis coli or APC) has facilitated the search for germ line mutations in affected individuals. Previous authors have used the R...
Topics
- Adenomatous Polyposis Coli
- Base Sequence
- DNA
- Electrophoresis, Polyacrylamide Gel
- Exons
- Female
- Genetic Linkage
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Nucleic Acid Heteroduplexes
- Pedigree
- Polymorphism, Genetic