Article
Functional dissection of the human spumaretrovirus transactivator identifies distinct classes of dominant-negative mutants.
Journal of virology - 1 Jan 1993
Venkatesh L K, Yang C, Theodorakis P A, Chinnadurai G
Abstract excerpt
The bel1 gene of human spumaretrovirus (HSRV) codes for a 300-amino-acid nuclear protein, termed Bel1, that can strongly activate transcription from the cognate long terminal repeat (LTR) by at least 200-fold. Bel1 can also activate human immunodeficiency virus type 1 (HIV-1) LTR expression. By u...
Topics
- Amino Acid Sequence
- Animals
- Cell Compartmentation
- Cell Line
- DNA Mutational Analysis
- Genes, Dominant
- Genes, Viral
- HIV-1
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Phosphorylation
- Protein Sorting Signals
- Repetitive Sequences, Nucleic Acid
- Spumavirus
- Structure-Activity Relationship
- Transcription, Genetic
- Transcriptional Activation