Article
Phosphorylation of ORF1p is required for L1 retrotransposition.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015
Cook Pamela R, Jones Charles E, Furano Anthony V
Abstract excerpt
Although members of the L1 (LINE-1) clade of non-LTR retrotransposons can be deleterious, the L1 clade has remained active in most mammals for ∼100 million years and generated almost 40% of the human genome. The details of L1-host interaction are largely unknown, however. Here we report that L1 activity requires phosphorylation of the protein encoded by the L1 ORF1 (ORF1p). Critical phospho-acceptor residues (two...
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