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Article

Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number.

Journal of virology - 1 Dec 1991

McBride A A, Howley P M

Abstract excerpt

The E2 open reading frame of bovine papillomavirus type 1 (BPV-1) encodes at least three proteins with transcriptional regulatory properties. The full-length E2 open reading frame encodes a transcriptional transactivator, and the 3' region encodes two smaller polypeptides that repress E2-mediated transactivation. The full-length gene product is also required for viral DNA replication. We have demonstrated that...

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Identifiers

PMID: 1658358
DOI: 10.1128/JVI.65.12.6528-6534.1991
PMCID: PMC250703

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Source receipt: pubmed, retrieved 7 Sept 2026.

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