Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number.

doi:10.1128/JVI.65.12.6528-6534.1991

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Article

Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number.

Journal of virology - 1 Dec 1991

McBride A A, Howley P M

Abstract excerpt

The E2 open reading frame of bovine papillomavirus type 1 (BPV-1) encodes at least three proteins with transcriptional regulatory properties. The full-length E2 open reading frame encodes a transcriptional transactivator, and the 3' region encodes two smaller polypeptides that repress E2-mediated transactivation. The full-length gene product is also required for viral DNA replication. We have demonstrated that...

Topics

Amino Acid Sequence
Animals
Bovine papillomavirus 1
Cell Line
Cell Line, Transformed
DNA
DNA, Viral
Gene Expression Regulation, Viral
Molecular Sequence Data
Mutagenesis, Site-Directed
Open Reading Frames

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phosphorylation

Plasmids

Serine

Transcription, Genetic

Transcriptional Activation

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1658358
DOI: 10.1128/JVI.65.12.6528-6534.1991
PMCID: PMC250703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1658358-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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