Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection.

doi:10.1111/j.1440-1746.2003.03318.x

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Article

Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection.

Journal of gastroenterology and hepatology - 1 May 2004

Nakashima Hisashi, Furusyo Norihiro, Kubo Norihiko, Kashiwagi Kenichiro, Etoh Yoshitaka, Kashiwagi Seizaburou, Hayashi Jun

Abstract excerpt

BACKGROUND AND AIM: Hepatitis B virus (HBV) genotype C has a more severe pathogenesis than genotype B in Japan. We retrospectively investigated the relationship between HBV genotype and the core promoter (CP) (nt 1762 and 1764) and precore (PreC) (nt 1896) mutations of the HBV genome. METHODS: A total of 129 Japanese patients (42 genotype B and 87 genotype C) with chronic HBV infection, living in two different...

Topics

Adult
Alanine Transaminase
DNA, Viral
Enzyme-Linked Immunosorbent Assay
Female
Genome, Viral
Genotype
Hepatitis B virus
Hepatitis B, Chronic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Japan

Liver Function Tests

Male

Middle Aged

Point Mutation

Promoter Regions, Genetic

Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 15086598
DOI: 10.1111/j.1440-1746.2003.03318.x

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